Hepatocytes (liver cells) are the Major Site of Insulin Clearance
"Adaptive decreases in the rate of hepatic insulin clearance (Ader et al., 2014; Jung et al., 2018) have been observed during insulin resistance and act to compensate for decreased insulin sensitivity (Jung et al., 2018)."
[Journal of Cell Biology]
http://jcb.rupress.org/content/217/7/2273